MolNFT v1 · #139848 · protein

Structure of coxsackievirus A6 (CVA6) virus a-particle

5XS4 · Genome polyprotein: “Structure of coxsackievirus A6 (CVA6) virus a-particle”. Electron microscopy, 7 pockets (best druggability 0.70). MolNFT v1 #139848 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 5XS4
Type: protein
Length: 626 residues
Chains: 3
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Genome polyprotein
UniProt: A0A0K2BNC7
Pockets: 7 · best druggability 0.70

Structure

electron microscopy · 3 distinct chains · 10% helix, 32% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Genome polyprotein	protein	213	8% helix, 28% strand	A0A0K2BNC7
B	Genome polyprotein	protein	203	14% helix, 35% strand	A0A0K2BNC7
C	Genome polyprotein	protein	210	9% helix, 33% strand	A0A0K2BNC7

Pockets

7 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	339	0.70	0.83	48	empty
2	164	0.56	0.81	24	empty
3	94	0.46	0.80	18	empty
4	58	0.40	0.80	21	empty
5	109	0.37	0.75	18	empty

Interfaces

3 interfaces between chains.

A–C · 2587 Å² buried · 34 hydrogen bonds · protein-protein
A–B · 1643 Å² buried · 27 hydrogen bonds · protein-protein
B–C · 1563 Å² buried · 11 hydrogen bonds · protein-protein

Compared structures

5XS4 · Structure of Coxsackievirus A6 (CVA6) virus A-particle · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt A0A0K2BNC7
Elsewhere: RCSB PDB 5XS4 · PDBe 5XS4 · UniProt A0A0K2BNC7

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