MolNFT v1 · #139834 · protein
Crystal structure of human monoclonal antibody H3V-47
5XRQ · Fab H3V-47 heavy chain: “Crystal structure of human monoclonal antibody H3V-47”. X-ray diffraction, 9 pockets (best druggability 0.56). MolNFT v1 #139834 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 5XRQ
- Type
- protein
- Length
- 864 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Fab H3V-47 heavy chain; Fab H3V-47 light chain
- UniProt
- Q6N089, Q8TCD0
- Pockets
- 9 · best druggability 0.56
Structure
x-ray diffraction · 4 distinct chains · 8% helix, 51% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| H | Fab H3V-47 heavy chain | protein | 220 | 10% helix, 53% strand | Q6N089 |
| L | Fab H3V-47 light chain | protein | 213 | 7% helix, 53% strand | Q8TCD0 |
| A | Fab H3V-47 heavy chain | protein | 219 | 8% helix, 48% strand | Q6N089 |
| B | Fab H3V-47 light chain | protein | 212 | 6% helix, 49% strand | Q8TCD0 |
Pockets
9 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 427 | 0.56 | 0.74 | 56 | empty |
| 2 | 414 | 0.56 | 0.73 | 53 | empty |
| 3 | 54 | 0.49 | 0.87 | 21 | empty |
| 4 | 142 | 0.42 | 0.75 | 27 | empty |
| 5 | 93 | 0.35 | 0.74 | 18 | empty |
Interfaces
3 interfaces between chains.
- A–B · 1601 Ų buried · 16 hydrogen bonds · protein-protein
- H–L · 1487 Ų buried · 13 hydrogen bonds · protein-protein
- H–A · 397 Ų buried · 5 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 8 disulfide (disulfide).
Compared structures
- 5XRQ · Crystal structure of human monoclonal antibody H3v-47 · the same entry in another collection · chain H against H, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q6N089
- Every structure of UniProt Q8TCD0
- Elsewhere: RCSB PDB 5XRQ · PDBe 5XRQ · UniProt Q6N089 · UniProt Q8TCD0
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.