MolNFT v1 · #13976 · protein
Crystal structure of chromobacterium violaceum phenylalanine hydroxylase, structure has bound iron (III) and oxidized cofactor 7, 8-dihydrobiopterin
1LTZ · Phenylalanine-4-hydroxylase: “Crystal structure of chromobacterium violaceum phenylalanine hydroxylase, structure has bound iron (III) and…”. X-ray diffraction, 3 ligands (HBI, FE, CL), 2 pockets (best druggability 0.74). MolNFT v1…
- PDB
- 1LTZ
- Type
- protein
- Length
- 274 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Phenylalanine-4-hydroxylase
- EC
- 1.14.16.1
- UniProt
- P30967
- Ligands
- HBI, FE, CL
- Pockets
- 2 · best druggability 0.74
Structure
x-ray diffraction · 1 distinct chain · 46% helix, 12% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Phenylalanine-4-hydroxylase (EC 1.14.16.1) | protein | 274 | 46% helix, 12% strand | P30967 |
Ligands and binding sites
- HBI · 7,8-dihydrobiopterin · ligand · chains A
- FE · Fe (III) ion · metal · chains A
- CL · Chloride ion · ion · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 377 | 0.74 | 0.85 | 42 | HBI |
| 2 | 81 | 0.42 | 0.79 | 20 | CL |
Compared structures
- 1LTZ · Crystal structure of chromobacterium violaceum phenylalanine hydroxylase, structure has… · the same entry in another collection · chain A against A, TM-score 1.00
- P30967 · AlphaFold monomer V2.0 prediction for phenylalanine-4-hydroxylase (P30967) · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P30967
- Elsewhere: RCSB PDB 1LTZ · PDBe 1LTZ · UniProt P30967
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