MolNFT v1 · #139599 · protein
Crystal structure of plant receptor ERL2 in complexe with EPFL4
5XKN · Epidermal patterning factor-like protein 4: “Crystal structure of plant receptor ERL2 in complexe with EPFL4”. X-ray diffraction, 8 pockets (best druggability 0.74). MolNFT v1 #139599 on GenesisL1: 3D structure, binding sites and…
- PDB
- 5XKN
- Type
- protein
- Length
- 1,148 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Epidermal patterning factor-like protein 4; Lrr receptor-like SERINE/THREONINE-protein…
- EC
- 2.7.11.1
- UniProt
- Q2V3I3, Q6XAT2
- Pockets
- 8 · best druggability 0.74
Structure
x-ray diffraction · 2 distinct chains · 17% helix, 16% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| E, F | Epidermal patterning factor-like protein 4 | protein | 34 | 0% helix, 32% strand | Q2V3I3 |
| A, B | Lrr receptor-like SERINE/THREONINE-protein kinase ERL2 (EC 2.7.11.1) | protein | 540 | 18% helix, 15% strand | Q6XAT2 |
Pockets
8 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 67 | 0.74 | 0.98 | 24 | empty |
| 2 | 74 | 0.74 | 0.96 | 25 | empty |
| 3 | 50 | 0.69 | 0.97 | 17 | empty |
| 4 | 86 | 0.34 | 0.74 | 19 | empty |
| 5 | 69 | 0.30 | 0.73 | 13 | empty |
Interfaces
5 interfaces between chains.
- A–F · 1007 Ų buried · 20 hydrogen bonds · protein-protein
- E–B · 983 Ų buried · 14 hydrogen bonds · protein-protein
- E–A · 107 Ų buried · 0 hydrogen bonds · protein-protein
- B–F · 80 Ų buried · 0 hydrogen bonds · protein-protein
- A–B · 32 Ų buried · 0 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 6 disulfide (disulfide).
Compared structures
- 5XKN · Crystal structure of plant receptor ERL2 in complexe with EPFL4 · the same entry in another collection · chain F against F, TM-score 1.00
- Q6XAT2 · AlphaFold monomer V2.0 prediction for lrr receptor-like SERINE/THREONINE-protein kinase… · a predicted model of the same protein · chain B against A, TM-score 0.98
- Q2V3I3 · AlphaFold monomer V2.0 prediction for epidermal patterning factor- like protein 4 (Q2V3I3) · a predicted model of the same protein · chain F against A, TM-score 0.56
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q2V3I3
- Every structure of UniProt Q6XAT2
- Elsewhere: RCSB PDB 5XKN · PDBe 5XKN · UniProt Q2V3I3 · UniProt Q6XAT2
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