MolNFT v1 · #139555 · protein

Tead in complex with fragment

5XJD · Transcriptional enhancer factor tef-3: “Tead in complex with fragment”. X-ray diffraction, 1 ligand (87L), 5 pockets (best druggability 0.82). MolNFT v1 #139555 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 5XJD
Type: protein
Length: 421 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Transcriptional enhancer factor tef-3
UniProt: Q62296
Ligands: 87L
Pockets: 5 · best druggability 0.82

Structure

x-ray diffraction · 2 distinct chains · 18% helix, 50% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Transcriptional enhancer factor tef-3	protein	209	17% helix, 51% strand	Q62296
B	Transcriptional enhancer factor tef-3	protein	212	18% helix, 50% strand	Q62296

Ligands and binding sites

87L · (2S)-2-phenyl-2-pyrrol-1-yl-ethanoic acid · ligand · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

5 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	275	0.82	0.93	35	empty
2	304	0.81	0.91	44	empty
3	228	0.75	0.88	28	87L
4	63	0.33	0.76	23	empty
5	73	0.32	0.74	15	empty

Interfaces

1 interface between chains.

A–B · 636 Å² buried · 6 hydrogen bonds · protein-protein

Compared structures

5XJD · TEAD in complex with fragment · the same entry in another collection · chain A against A, TM-score 1.00
Q62296 · AlphaFold monomer V2.0 prediction for transcriptional enhancer factor tef-3 (Q62296) · a predicted model of the same protein · chain A against A, TM-score 0.97

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q62296
Elsewhere: RCSB PDB 5XJD · PDBe 5XJD · UniProt Q62296

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