MolNFT v1 · #139387 · protein
Crystal structure of mycobacterium tuberculosis extracytoplasmic function sigma factor sigj
5XE7 · Ecf RNA polymerase sigma factor sigj: “Crystal structure of mycobacterium tuberculosis extracytoplasmic function sigma factor sigj”. X-ray diffraction, 8 pockets (best druggability 0.83). MolNFT v1 #139387 on GenesisL1: 3D…
- PDB
- 5XE7
- Type
- protein
- Length
- 557 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Ecf RNA polymerase sigma factor sigj
- UniProt
- L0TCG5
- Pockets
- 8 · best druggability 0.83
Structure
x-ray diffraction · 2 distinct chains · 46% helix, 15% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Ecf RNA polymerase sigma factor sigj | protein | 277 | 46% helix, 14% strand | L0TCG5 |
| B | Ecf RNA polymerase sigma factor sigj | protein | 280 | 46% helix, 15% strand | L0TCG5 |
Pockets
8 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 291 | 0.83 | 0.93 | 32 | empty |
| 2 | 372 | 0.78 | 0.87 | 32 | empty |
| 3 | 1175 | 0.76 | 0.79 | 125 | empty |
| 4 | 138 | 0.56 | 0.82 | 27 | empty |
| 5 | 187 | 0.55 | 0.79 | 27 | empty |
Interfaces
1 interface between chains.
- A–B · 767 Ų buried · 7 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 10 modified (engineered).
Compared structures
- 5XE7 · Crystal structure of Mycobacterium tuberculosis extracytoplasmic function sigma factor… · the same entry in another collection · chain A against A, TM-score 1.00
- L0TCG5 · AlphaFold monomer V2.0 prediction for ecf RNA polymerase sigma factor sigj (L0TCG5) · a predicted model of the same protein · chain A against A, TM-score 0.94
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt L0TCG5
- Elsewhere: RCSB PDB 5XE7 · PDBe 5XE7 · UniProt L0TCG5
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