MolNFT v1 · #139250 · protein
Crystal structure of inositol 1,4,5-trisphosphate receptor cytosolic domain
5XA0 · Inositol 1,4,5-trisphosphate receptor type 1: “Crystal structure of inositol 1,4,5-trisphosphate receptor cytosolic domain”. X-ray diffraction, 20 pockets (best druggability 0.87). MolNFT v1 #139250 on GenesisL1: 3D structure…
- PDB
- 5XA0
- Type
- protein
- Length
- 2,504 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Inositol 1,4,5-trisphosphate receptor type 1
- UniProt
- P11881
- Pockets
- 20 · best druggability 0.87
Structure
x-ray diffraction · 1 distinct chain · 44% helix, 6% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Inositol 1,4,5-trisphosphate receptor type 1 | protein | 1252 | 44% helix, 6% strand | P11881 |
Pockets
20 pockets found on a 1 Å grid, 19 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 962 | 0.87 | 0.88 | 124 | empty |
| 2 | 541 | 0.87 | 0.92 | 64 | empty |
| 3 | 602 | 0.85 | 0.90 | 67 | empty |
| 4 | 296 | 0.82 | 0.93 | 52 | empty |
| 5 | 931 | 0.80 | 0.82 | 119 | empty |
Interfaces
1 interface between chains.
- A–B · 11 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 5XA0 · Crystal structure of inositol 1,4,5-trisphosphate receptor cytosolic domain · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P11881
- Elsewhere: RCSB PDB 5XA0 · PDBe 5XA0 · UniProt P11881
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