MolNFT v1 · #139249 · protein

Crystal structure of inositol 1,4,5-trisphosphate receptor large cytosolic domain

5X9Z · Inositol 1,4,5-trisphosphate receptor type 1: “Crystal structure of inositol 1,4,5-trisphosphate receptor large cytosolic domain”. X-ray diffraction, 20 pockets (best druggability 0.84). MolNFT v1 #139249 on GenesisL1: 3D structure…

PDB: 5X9Z
Type: protein
Length: 3,418 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Inositol 1,4,5-trisphosphate receptor type 1
UniProt: P11881
Pockets: 20 · best druggability 0.84

Structure

x-ray diffraction · 2 distinct chains · 51% helix, 5% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Inositol 1,4,5-trisphosphate receptor type 1	protein	1710	51% helix, 5% strand	P11881
B	Inositol 1,4,5-trisphosphate receptor type 1	protein	1708	51% helix, 5% strand	P11881

Pockets

20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	938	0.84	0.86	93	empty
2	988	0.83	0.85	91	empty
3	1177	0.82	0.83	136	empty
4	1110	0.81	0.83	94	empty
5	957	0.81	0.83	83	empty

Interfaces

1 interface between chains.

A–B · 324 Å² buried · 0 hydrogen bonds · protein-protein

Compared structures

5X9Z · Crystal structure of inositol 1,4,5-trisphosphate receptor large cytosolic domain · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P11881
Elsewhere: RCSB PDB 5X9Z · PDBe 5X9Z · UniProt P11881

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