MolNFT v1 · #139195 · protein
Structure of dcc FN456 domains
5X83 · Netrin receptor dcc: “Structure of dcc FN456 domains”. X-ray diffraction, 3 pockets (best druggability 0.56). MolNFT v1 #139195 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 5X83
- Type
- protein
- Length
- 586 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Netrin receptor dcc
- UniProt
- P43146
- Pockets
- 3 · best druggability 0.56
Structure
x-ray diffraction · 4 distinct chains · 2% helix, 49% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Netrin receptor dcc | protein | 94 | 0% helix, 51% strand | P43146 |
| B | Netrin receptor dcc | protein | 202 | 3% helix, 48% strand | P43146 |
| C | Netrin receptor dcc | protein | 95 | 0% helix, 51% strand | P43146 |
| D | Netrin receptor dcc | protein | 195 | 4% helix, 48% strand | P43146 |
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 315 | 0.56 | 0.76 | 43 | empty |
| 2 | 103 | 0.36 | 0.74 | 23 | empty |
| 3 | 87 | 0.36 | 0.76 | 20 | empty |
Interfaces
4 interfaces between chains.
- B–D · 882 Ų buried · 5 hydrogen bonds · protein-protein
- A–D · 431 Ų buried · 3 hydrogen bonds · protein-protein
- B–C · 425 Ų buried · 3 hydrogen bonds · protein-protein
- A–B · 116 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P43146
- Elsewhere: RCSB PDB 5X83 · PDBe 5X83 · UniProt P43146
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