MolNFT v1 · #139117 · protein

Prefusion structure of MERS-cov spike glycoprotein, conformation 2

5X5F · S protein: “Prefusion structure of MERS-cov spike glycoprotein, conformation 2”. Electron microscopy, 20 pockets (best druggability 0.79). MolNFT v1 #139117 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 5X5F
Type: protein
Length: 3,423 residues
Chains: 3
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: S protein
UniProt: W6A028
Pockets: 20 · best druggability 0.79

Structure

electron microscopy · 1 distinct chain · 20% helix, 22% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, C	S protein	protein	1141	20% helix, 22% strand	W6A028

Pockets

20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	498	0.79	0.86	51	empty
2	579	0.79	0.85	53	empty
3	197	0.79	0.93	52	empty
4	280	0.77	0.89	37	empty
5	606	0.76	0.82	52	empty

Interfaces

3 interfaces between chains.

B–C · 5603 Å² buried · 74 hydrogen bonds · protein-protein
A–B · 5571 Å² buried · 67 hydrogen bonds · protein-protein
A–C · 4497 Å² buried · 55 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 34 disulfide (disulfide).

Compared structures

5X5F · Prefusion structure of MERS-CoV spike glycoprotein, conformation 2 · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt W6A028
Elsewhere: RCSB PDB 5X5F · PDBe 5X5F · UniProt W6A028

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.