MolNFT v1 · #139084 · protein

Crystal structure of Fab fragment of anti-CD147 monoclonal antibody 6H8

5X4G · 6H8 Fab heavy chain: “Crystal structure of Fab fragment of anti-CD147 monoclonal antibody 6H8”. X-ray diffraction, 3 pockets (best druggability 0.69). MolNFT v1 #139084 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 5X4G
Type: protein
Length: 428 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: 6H8 Fab heavy chain; 6H8 Fab light chain
Pockets: 3 · best druggability 0.69

Structure

x-ray diffraction · 2 distinct chains · 8% helix, 52% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	6H8 Fab heavy chain	protein	215	11% helix, 52% strand	—
B	6H8 Fab light chain	protein	213	6% helix, 53% strand	—

Pockets

3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	848	0.69	0.75	90	empty
2	190	0.54	0.79	29	empty
3	86	0.33	0.74	25	empty

Interfaces

1 interface between chains.

A–B · 1867 Å² buried · 20 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 4 disulfide (disulfide).

Compared structures

5X4G · Crystal structure of Fab fragment of anti-CD147 monoclonal antibody 6H8 · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 5X4G · PDBe 5X4G

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