MolNFT v1 · #138931 · protein + RNA

Structure of APUM23-ggaauugacgg

5WZH · Pumilio homolog 23: “Structure of APUM23-ggaauugacgg”. X-ray diffraction, 2 pockets (best druggability 0.61). MolNFT v1 #138931 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 5WZH
Type: protein + RNA
Length: 544 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Pumilio homolog 23; RNA (5'-R(*GP*GP*AP*AP*UP*UP*GP*AP*CP*GP*G)-3')
UniProt: Q9C552
Pockets: 2 · best druggability 0.61

Structure

x-ray diffraction · 2 distinct chains · 73% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Pumilio homolog 23	protein	533	73% helix, 0% strand	Q9C552
B	RNA (5'-R(GPGPAPAPUPUPGPAPCPGP*G)-3')	rna	11	—	—

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	193	0.61	0.83	31	empty
2	55	0.26	0.73	14	empty

Interfaces

1 interface between chains.

A–B · 1799 Å² buried · 65 hydrogen bonds · protein-nucleic

Compared structures

5WZH · Structure of APUM23-GGAAUUGACGG · the same entry in another collection · chain A against A, TM-score 1.00
Q9C552 · AlphaFold monomer V2.0 prediction for pumilio homolog 23 (Q9C552) · a predicted model of the same protein · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9C552
Elsewhere: RCSB PDB 5WZH · PDBe 5WZH · UniProt Q9C552

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