MolNFT v1 · #138918 · protein

Solution structure of E.COLI hdea

5WYO · Acid stress chaperone hdea: “Solution structure of E.COLI hdea”. Solution nmr, 3 pockets (best druggability 0.78). MolNFT v1 #138918 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 5WYO
Type: protein
Length: 178 residues
Chains: 2
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Acid stress chaperone hdea
UniProt: P0AET0
Pockets: 3 · best druggability 0.78

Structure

solution nmr · 1 distinct chain · 52% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Acid stress chaperone hdea	protein	89	52% helix, 0% strand	P0AET0

Pockets

3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	96	0.78	0.98	24	empty
2	118	0.47	0.79	22	empty
3	78	0.42	0.79	19	empty

Interfaces

1 interface between chains.

A–B · 1797 Å² buried · 16 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 2 disulfide (disulfide).

Compared structures

5WYO · Solution structure of E.coli HdeA · the same entry in another collection · chain A against A, TM-score 1.00
P0AET0 · AlphaFold monomer V2.0 prediction for acid stress chaperone hdea (P0AET0) · a predicted model of the same protein · chain A against A, TM-score 0.71

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P0AET0
Elsewhere: RCSB PDB 5WYO · PDBe 5WYO · UniProt P0AET0

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