MolNFT v1 · #138916 · protein

Crystal structure of an anti-CONNEXIN26 scfv

5WYM · Anti-CONNEXIN26 SCFV,IG heavy CHAIN,LINKER,ANTI-CONNEXIN26…: “Crystal structure of an anti-CONNEXIN26 scfv”. X-ray diffraction, 1 pocket (best druggability 0.54). MolNFT v1 #138916 on GenesisL1: 3D structure, binding sites and…

PDB: 5WYM
Type: protein
Length: 457 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Anti-CONNEXIN26 SCFV,IG heavy CHAIN,LINKER,ANTI-CONNEXIN26 SCFV,IG light chain
Pockets: 1 · best druggability 0.54

Structure

x-ray diffraction · 2 distinct chains · 4% helix, 50% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Anti-CONNEXIN26 SCFV,IG heavy CHAIN,LINKER,ANTI-CONNEXIN26 SCFV,IG light chain	protein	229	4% helix, 50% strand	—
C	Anti-CONNEXIN26 SCFV,IG heavy CHAIN,LINKER,ANTI-CONNEXIN26 SCFV,IG light chain	protein	228	4% helix, 50% strand	—

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	255	0.54	0.77	35	empty

Interfaces

1 interface between chains.

A–C · 138 Å² buried · 0 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 4 disulfide (disulfide).

Compared structures

5WYM · Crystal structure of an anti-connexin26 scFv · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 5WYM · PDBe 5WYM

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