MolNFT v1 · #138854 · protein
Crystal structure of ENP1
5WWO · Essential nuclear protein 1: “Crystal structure of ENP1”. X-ray diffraction, 1 pocket (best druggability 0.81). MolNFT v1 #138854 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 5WWO
- Type
- protein
- Length
- 561 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Essential nuclear protein 1; Protein LTV1
- UniProt
- P38333, P34078
- Pockets
- 1 · best druggability 0.81
Structure
x-ray diffraction · 3 distinct chains · 69% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Essential nuclear protein 1 | protein | 261 | 70% helix, 0% strand | P38333 |
| B | Essential nuclear protein 1 | protein | 254 | 69% helix, 0% strand | P38333 |
| C | Protein LTV1 | protein | 46 | 70% helix, 0% strand | P34078 |
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1028 | 0.81 | 0.82 | 87 | empty |
Interfaces
3 interfaces between chains.
- A–C · 1537 Ų buried · 14 hydrogen bonds · protein-protein
- A–B · 551 Ų buried · 7 hydrogen bonds · protein-protein
- B–C · 343 Ų buried · 4 hydrogen bonds · protein-protein
Compared structures
- 5WWO · Crystal structure of Enp1 · the same entry in another collection · chain A against A, TM-score 1.00
- P38333 · AlphaFold monomer V2.0 prediction for essential nuclear protein 1 (P38333) · a predicted model of the same protein · chain A against A, TM-score 1.00
- P34078 · AlphaFold monomer V2.0 prediction for protein LTV1 (P34078) · a predicted model of the same protein · chain C against A, TM-score 0.77
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P38333
- Every structure of UniProt P34078
- Elsewhere: RCSB PDB 5WWO · PDBe 5WWO · UniProt P38333 · UniProt P34078
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