MolNFT v1 · #138851 · protein
Crystal structure of the schizogenesis pombe kinetochore MIS12C subcomplex
5WWL · Centromere protein MIS12: “Crystal structure of the schizogenesis pombe kinetochore MIS12C subcomplex”. X-ray diffraction, 3 pockets (best druggability 0.66). MolNFT v1 #138851 on GenesisL1: 3D structure, binding sites and pockets…
- PDB
- 5WWL
- Type
- protein
- Length
- 369 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Centromere protein MIS12; Kinetochore protein NNF1
- UniProt
- Q9Y738, Q09858
- Pockets
- 3 · best druggability 0.66
Structure
x-ray diffraction · 2 distinct chains · 83% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| M | Centromere protein MIS12 | protein | 214 | 79% helix, 0% strand | Q9Y738 |
| N | Kinetochore protein NNF1 | protein | 155 | 88% helix, 0% strand | Q09858 |
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 402 | 0.66 | 0.79 | 33 | empty |
| 2 | 77 | 0.43 | 0.80 | 22 | empty |
| 3 | 75 | 0.40 | 0.79 | 16 | empty |
Interfaces
1 interface between chains.
- M–N · 4765 Ų buried · 36 hydrogen bonds · protein-protein
Compared structures
- 5WWL · Crystal structure of the Schizogenesis pombe kinetochore Mis12C subcomplex · the same entry in another collection · chain M against M, TM-score 1.00
- Q9Y738 · AlphaFold monomer V2.0 prediction for centromere protein MIS12 (Q9Y738) · a predicted model of the same protein · chain M against A, TM-score 0.96
- Q09858 · AlphaFold monomer V2.0 prediction for kinetochore protein NNF1 (Q09858) · a predicted model of the same protein · chain N against A, TM-score 0.56
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9Y738
- Every structure of UniProt Q09858
- Elsewhere: RCSB PDB 5WWL · PDBe 5WWL · UniProt Q9Y738 · UniProt Q09858
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.