MolNFT v1 · #138835 · protein
Crystal structure of SET7, a novel histone methyltransferase in schizossacharomyces pombe
5WW0 · Set domain-containing protein 7: “Crystal structure of SET7, a novel histone methyltransferase in schizossacharomyces pombe”. X-ray diffraction, 1 ligand (SO4), 3 pockets (best druggability 0.80). MolNFT v1 #138835 on GenesisL1: 3D…
- PDB
- 5WW0
- Type
- protein
- Length
- 243 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Set domain-containing protein 7
- EC
- 2.1.1.43
- UniProt
- Q9Y7Q6
- Ligands
- SO4
- Pockets
- 3 · best druggability 0.80
Structure
x-ray diffraction · 2 distinct chains · 14% helix, 43% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Set domain-containing protein 7 (EC 2.1.1.43) | protein | 123 | 15% helix, 41% strand | Q9Y7Q6 |
| B | Set domain-containing protein 7 (EC 2.1.1.43) | protein | 120 | 13% helix, 45% strand | Q9Y7Q6 |
Ligands and binding sites
- SO4 · Sulfate ion · ion · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 134 | 0.80 | 0.97 | 28 | empty |
| 2 | 130 | 0.44 | 0.77 | 28 | empty |
| 3 | 59 | 0.33 | 0.77 | 16 | SO4 |
Interfaces
1 interface between chains.
- A–B · 1717 Ų buried · 34 hydrogen bonds · protein-protein
Compared structures
- 5WW0 · Crystal structure of Set7, a novel histone methyltransferase in Schizossacharomyces pombe · the same entry in another collection · chain A against A, TM-score 1.00
- Q9Y7Q6 · AlphaFold monomer V2.0 prediction for set domain-containing protein 7 (Q9Y7Q6) · a predicted model of the same protein · chain B against A, TM-score 0.93
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9Y7Q6
- Elsewhere: RCSB PDB 5WW0 · PDBe 5WW0 · UniProt Q9Y7Q6
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