Crystal structure of sigw in complex with its anti-sigma rsiw, a zinc binding form

Structure

x-ray diffraction · 4 distinct chains · 73% helix, 0% strand (DSSP).

Ligands and binding sites

• ZN · Zinc ion · metal · 2 copies · chains C, D

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Interfaces

6 interfaces between chains.

• A–C · 1734 Ų buried · 26 hydrogen bonds · protein-protein
• B–D · 1698 Ų buried · 24 hydrogen bonds · protein-protein
• A–D · 387 Ų buried · 3 hydrogen bonds · protein-protein
• B–C · 286 Ų buried · 3 hydrogen bonds · protein-protein
• C–D · 179 Ų buried · 0 hydrogen bonds · protein-protein

Compared structures

• 5WUQ · Crystal structure of SigW in complex with its anti-sigma RsiW, a zinc binding form · the same entry in another collection · chain D against D, TM-score 1.00
• Q45585 · AlphaFold monomer V2.0 prediction for ecf RNA polymerase sigma factor sigw (Q45585) · a predicted model of the same protein · chain B against A, TM-score 0.97
• Q45588 · AlphaFold monomer V2.0 prediction for anti-sigma-W factor rsiw (Q45588) · a predicted model of the same protein · chain C against A, TM-score 0.72

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt Q45585
• Every structure of UniProt Q45588
• Elsewhere: RCSB PDB 5WUQ · PDBe 5WUQ · UniProt Q45585 · UniProt Q45588