MolNFT v1 · #13877 · protein
Crystal structure of the fosfomycin resistance protein (fosa) containing bound substrate
1LQP · Probable fosfomycin resistance protein: “Crystal structure of the fosfomycin resistance protein (fosa) containing bound substrate”. X-ray diffraction, 3 ligands (FCN, K, MN), 2 pockets (best druggability 0.59). MolNFT v1 #13877 on…
- PDB
- 1LQP
- Type
- protein
- Length
- 268 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Probable fosfomycin resistance protein
- EC
- 2.5.1.18
- UniProt
- Q9I4K6
- Ligands
- FCN, K, MN
- Pockets
- 2 · best druggability 0.59
Structure
x-ray diffraction · 1 distinct chain · 25% helix, 38% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Probable fosfomycin resistance protein (EC 2.5.1.18) | protein | 134 | 25% helix, 38% strand | Q9I4K6 |
Ligands and binding sites
- FCN · Fosfomycin · ligand · 4 copies · chains A, B
- K · Potassium ion · metal · 2 copies · chains A, B
- MN · Manganese (II) ion · metal · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 178 | 0.59 | 0.82 | 25 | MN, FCN |
| 2 | 179 | 0.54 | 0.79 | 26 | MN, FCN |
Interfaces
1 interface between chains.
- A–B · 2691 Ų buried · 50 hydrogen bonds · protein-protein
Compared structures
- 1LQP · Crystal structure of the fosfomycin resistance protein (fosa) containing bound substrate · the same entry in another collection · chain A against A, TM-score 1.00
- Q9I4K6 · AlphaFold monomer V2.0 prediction for glutathione transferase fosa (Q9I4K6) · a predicted model of the same protein · chain B against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9I4K6
- Elsewhere: RCSB PDB 1LQP · PDBe 1LQP · UniProt Q9I4K6
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.