MolNFT v1 · #138767 · protein
Crystal structure of an endonuclease
5WTJ · CRISPR-associated endoribonuclease C2C2: “Crystal structure of an endonuclease”. X-ray diffraction, 20 pockets (best druggability 0.82). MolNFT v1 #138767 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 5WTJ
- Type
- protein
- Length
- 2,031 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- CRISPR-associated endoribonuclease C2C2
- EC
- 3.1.-.-
- UniProt
- P0DOC6
- Pockets
- 20 · best druggability 0.82
Structure
x-ray diffraction · 2 distinct chains · 54% helix, 1% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | CRISPR-associated endoribonuclease C2C2 (EC 3.1.-.-) | protein | 1019 | 53% helix, 2% strand | P0DOC6 |
| B | CRISPR-associated endoribonuclease C2C2 (EC 3.1.-.-) | protein | 1012 | 56% helix, 1% strand | P0DOC6 |
Pockets
20 pockets found on a 1 Å grid, 15 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1034 | 0.82 | 0.83 | 96 | empty |
| 2 | 808 | 0.80 | 0.83 | 68 | empty |
| 3 | 754 | 0.78 | 0.82 | 62 | empty |
| 4 | 1167 | 0.77 | 0.79 | 104 | empty |
| 5 | 861 | 0.73 | 0.77 | 73 | empty |
Interfaces
1 interface between chains.
- A–B · 198 Ų buried · 3 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 21 modified (engineered).
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P0DOC6
- Elsewhere: RCSB PDB 5WTJ · PDBe 5WTJ · UniProt P0DOC6
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