MolNFT v1 · #138753 · protein
L-cysteine-plp intermediate of nifs from helicobacter pylori
5WT4 · Cysteine desulfurase iscs: “L-cysteine-plp intermediate of nifs from helicobacter pylori”. X-ray diffraction, 1 ligand (C6P), 3 pockets (best druggability 0.47). MolNFT v1 #138753 on GenesisL1: 3D structure, binding sites and…
- PDB
- 5WT4
- Type
- protein
- Length
- 358 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Cysteine desulfurase iscs
- EC
- 2.8.1.7
- UniProt
- O25008
- Ligands
- C6P
- Pockets
- 3 · best druggability 0.47
Structure
x-ray diffraction · 1 distinct chain · 41% helix, 16% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Cysteine desulfurase iscs (EC 2.8.1.7) | protein | 358 | 41% helix, 16% strand | O25008 |
Ligands and binding sites
- C6P · N-({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methyl)-L-cysteine · ligand · chains A
- IPA · Isopropyl alcohol · additive · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 64 | 0.47 | 0.84 | 19 | C6P |
| 2 | 72 | 0.29 | 0.73 | 14 | IPA |
| 3 | 62 | 0.29 | 0.74 | 19 | empty |
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O25008
- Elsewhere: RCSB PDB 5WT4 · PDBe 5WT4 · UniProt O25008
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