MolNFT v1 · #138625 · protein
Crystal structure of eed in complex with EB22
5WP3 · Polycomb protein eed: “Crystal structure of eed in complex with EB22”. X-ray diffraction, 1 ligand (UNX), 4 pockets (best druggability 0.81). MolNFT v1 #138625 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 5WP3
- Type
- protein
- Length
- 462 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Polycomb protein eed; EB22
- UniProt
- O75530
- Ligands
- UNX
- Pockets
- 4 · best druggability 0.81
Structure
x-ray diffraction · 2 distinct chains · 22% helix, 36% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Polycomb protein eed | protein | 360 | 3% helix, 46% strand | O75530 |
| B | EB22 | protein | 102 | 88% helix, 0% strand | — |
Ligands and binding sites
- UNX · Unknown atom or ion · ion · 16 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 859 | 0.81 | 0.83 | 106 | UNX |
| 2 | 85 | 0.62 | 0.89 | 18 | empty |
| 3 | 68 | 0.50 | 0.85 | 19 | empty |
| 4 | 117 | 0.39 | 0.75 | 21 | empty |
Interfaces
1 interface between chains.
- A–B · 929 Ų buried · 7 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 1 disulfide (disulfide).
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O75530
- Elsewhere: RCSB PDB 5WP3 · PDBe 5WP3 · UniProt O75530
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.