MolNFT v1 · #138568 · protein
Structure of antibody 3D3 bound to the central conserved region of rsv G
5WNA · Mab 3D3 Fab heavy chain: “Structure of antibody 3D3 bound to the central conserved region of rsv G”. X-ray diffraction, 5 pockets (best druggability 0.86). MolNFT v1 #138568 on GenesisL1: 3D structure, binding sites and pockets in…
- PDB
- 5WNA
- Type
- protein
- Length
- 934 residues
- Chains
- 6
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Mab 3D3 Fab heavy chain; Mab 3D3 Fab light chain; Major surface glycoprotein G
- UniProt
- P03423
- Pockets
- 5 · best druggability 0.86
Structure
x-ray diffraction · 4 distinct chains · 11% helix, 50% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| H | Mab 3D3 Fab heavy chain | protein | 227 | 10% helix, 52% strand | — |
| L, D | Mab 3D3 Fab light chain | protein | 211 | 6% helix, 51% strand | — |
| B, A | Major surface glycoprotein G | protein | 30 | 37% helix, 7% strand | P03423 |
| C | Mab 3D3 Fab heavy chain | protein | 225 | 12% helix, 52% strand | — |
Pockets
5 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 941 | 0.86 | 0.88 | 79 | empty |
| 2 | 560 | 0.78 | 0.85 | 71 | empty |
| 3 | 193 | 0.48 | 0.76 | 29 | empty |
| 4 | 93 | 0.33 | 0.73 | 25 | empty |
| 5 | 62 | 0.31 | 0.76 | 14 | empty |
Interfaces
12 interfaces between chains.
- H–L · 2030 Ų buried · 15 hydrogen bonds · protein-protein
- C–D · 1989 Ų buried · 16 hydrogen bonds · protein-protein
- H–B · 864 Ų buried · 8 hydrogen bonds · protein-protein
- C–A · 856 Ų buried · 6 hydrogen bonds · protein-protein
- L–D · 545 Ų buried · 2 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 12 disulfide (disulfide).
Compared structures
- 5WNA · Structure of antibody 3D3 bound to the central conserved region of RSV G · the same entry in another collection · chain H against H, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P03423
- Elsewhere: RCSB PDB 5WNA · PDBe 5WNA · UniProt P03423
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