MolNFT v1 · #138497 · protein
VH1-69 germline antibody with cdr H3 sequence of CR9114
5WL2 · Heavy chain of VH1-69 germline antibody with cdr H3…: “VH1-69 germline antibody with cdr H3 sequence of CR9114”. X-ray diffraction, 13 pockets (best druggability 0.58). MolNFT v1 #138497 on GenesisL1: 3D structure, binding sites and…
- PDB
- 5WL2
- Type
- protein
- Length
- 862 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Heavy chain of VH1-69 germline antibody with cdr H3 sequence of CR9114; Germline-reverted…
- Pockets
- 13 · best druggability 0.58
Structure
x-ray diffraction · 3 distinct chains · 9% helix, 51% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| H | Heavy chain of VH1-69 germline antibody with cdr H3 sequence of CR9114 | protein | 219 | 10% helix, 52% strand | — |
| L, B | Germline-reverted light chain of CR9114 | protein | 211 | 8% helix, 51% strand | — |
| A | Heavy chain of VH1-69 germline antibody with cdr H3 sequence of CR9114 | protein | 221 | 10% helix, 51% strand | — |
Pockets
13 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 56 | 0.58 | 0.91 | 19 | empty |
| 2 | 263 | 0.48 | 0.73 | 36 | empty |
| 3 | 136 | 0.47 | 0.78 | 26 | empty |
| 4 | 107 | 0.40 | 0.76 | 27 | empty |
| 5 | 74 | 0.38 | 0.77 | 14 | empty |
Interfaces
3 interfaces between chains.
- H–L · 1678 Ų buried · 14 hydrogen bonds · protein-protein
- A–B · 1616 Ų buried · 15 hydrogen bonds · protein-protein
- L–B · 600 Ų buried · 5 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 8 disulfide (disulfide).
Compared structures
- 5WL2 · VH1-69 germline antibody with CDR H3 sequence of CR9114 · the same entry in another collection · chain H against H, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 5WL2 · PDBe 5WL2
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.