MolNFT v1 · #138482 · protein
Crystal structure of the parainfluenza virus 5 nucleoprotein- phosphoprotein complex
5WKN: “Crystal structure of the parainfluenza virus 5 nucleoprotein- phosphoprotein complex”. X-ray diffraction, 7 pockets (best druggability 0.75). MolNFT v1 #138482 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 5WKN
- Type
- protein
- Length
- 689 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Nucleoprotein; Phosphoprotein
- UniProt
- Q88435, P11208
- Pockets
- 7 · best druggability 0.75
Structure
x-ray diffraction · 4 distinct chains · 56% helix, 4% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Nucleoprotein | protein | 323 | 59% helix, 3% strand | Q88435 |
| C | Phosphoprotein | protein | 19 | 37% helix, 0% strand | P11208 |
| B | Nucleoprotein | protein | 328 | 58% helix, 5% strand | Q88435 |
| D | Phosphoprotein | protein | 19 | 0% helix, 0% strand | P11208 |
Pockets
7 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1068 | 0.75 | 0.78 | 97 | empty |
| 2 | 225 | 0.50 | 0.75 | 32 | empty |
| 3 | 200 | 0.48 | 0.75 | 39 | empty |
| 4 | 60 | 0.41 | 0.81 | 14 | empty |
| 5 | 61 | 0.34 | 0.77 | 23 | empty |
Interfaces
5 interfaces between chains.
- B–D · 805 Ų buried · 1 hydrogen bond · protein-protein
- A–C · 801 Ų buried · 3 hydrogen bonds · protein-protein
- A–B · 492 Ų buried · 4 hydrogen bonds · protein-protein
- A–D · 36 Ų buried · 0 hydrogen bonds · protein-protein
- C–B · 33 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 5WKN · Crystal structure of the parainfluenza virus 5 nucleoprotein-phosphoprotein complex · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q88435
- Every structure of UniProt P11208
- Elsewhere: RCSB PDB 5WKN · PDBe 5WKN · UniProt Q88435 · UniProt P11208
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