MolNFT v1 · #138446 · protein
Crystal structure of NAA80 bound to a bisubstrate analogue
5WJE · CG8481, isoform B: “Crystal structure of NAA80 bound to a bisubstrate analogue”. X-ray diffraction, 2 ligands (CMC, NH2), 2 pockets (best druggability 0.51). MolNFT v1 #138446 on GenesisL1: 3D structure, binding sites and pockets in…
- PDB
- 5WJE
- Type
- protein
- Length
- 163 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- CG8481, isoform B; Actin N-terminus peptide
- EC
- 2.3.1.-
- UniProt
- Q59DX8
- Ligands
- CMC, NH2
- Pockets
- 2 · best druggability 0.51
Structure
x-ray diffraction · 2 distinct chains · 34% helix, 28% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | CG8481, isoform B (EC 2.3.1.-) | protein | 159 | 35% helix, 29% strand | Q59DX8 |
| B | Actin N-terminus peptide | protein | 4 | 0% helix, 0% strand | — |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 152 | 0.51 | 0.79 | 22 | CMC |
| 2 | 126 | 0.41 | 0.75 | 20 | NH2 |
Interfaces
1 interface between chains.
- A–B · 423 Ų buried · 12 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 1 covalent (covalent ligand).
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q59DX8
- Elsewhere: RCSB PDB 5WJE · PDBe 5WJE · UniProt Q59DX8
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