MolNFT v1 · #138425 · protein
Structure of the TRF1-TERB1 interface
5WIR · TERB1-tbm: “Structure of the TRF1-TERB1 interface”. X-ray diffraction, 6 pockets (best druggability 0.59). MolNFT v1 #138425 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 5WIR
- Type
- protein
- Length
- 429 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- TERB1-tbm; Telomeric repeat-binding factor 1
- UniProt
- P54274
- Pockets
- 6 · best druggability 0.59
Structure
x-ray diffraction · 3 distinct chains · 66% helix, 2% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| D | TERB1-tbm | protein | 7 | 0% helix, 14% strand | — |
| B, A | Telomeric repeat-binding factor 1 | protein | 205 | 72% helix, 0% strand | P54274 |
| C | TERB1-tbm | protein | 12 | 0% helix, 17% strand | — |
Pockets
6 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 142 | 0.59 | 0.84 | 23 | empty |
| 2 | 104 | 0.55 | 0.84 | 24 | empty |
| 3 | 106 | 0.39 | 0.75 | 23 | empty |
| 4 | 85 | 0.35 | 0.75 | 19 | empty |
| 5 | 61 | 0.33 | 0.76 | 12 | empty |
Interfaces
3 interfaces between chains.
- B–A · 1344 Ų buried · 15 hydrogen bonds · protein-protein
- C–A · 769 Ų buried · 16 hydrogen bonds · protein-protein
- D–B · 579 Ų buried · 9 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P54274
- Elsewhere: RCSB PDB 5WIR · PDBe 5WIR · UniProt P54274
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