MolNFT v1 · #138381 · protein

Crystal structure of Fab fragment of anti-fcrn antibody dx-2507

5WHJ · Dx-2507 Fab heavy chain: “Crystal structure of Fab fragment of anti-fcrn antibody dx-2507”. X-ray diffraction, 5 pockets (best druggability 0.64). MolNFT v1 #138381 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 5WHJ
Type: protein
Length: 428 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Dx-2507 Fab heavy chain; Dx-2507 Fab light chain
UniProt: S6BAN1, Q6NS95
Pockets: 5 · best druggability 0.64

Structure

x-ray diffraction · 2 distinct chains · 9% helix, 50% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
H	Dx-2507 Fab heavy chain	protein	217	11% helix, 49% strand	S6BAN1
L	Dx-2507 Fab light chain	protein	211	8% helix, 50% strand	Q6NS95

Pockets

5 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	174	0.64	0.85	34	empty
2	147	0.40	0.73	26	empty
3	58	0.31	0.75	18	empty
4	72	0.29	0.72	18	empty
5	64	0.28	0.73	18	empty

Interfaces

1 interface between chains.

H–L · 1463 Å² buried · 10 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 4 disulfide (disulfide).

Compared structures

5WHJ · Crystal structure of Fab fragment of anti-FcRn antibody DX-2507 · the same entry in another collection · chain H against H, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt S6BAN1
Every structure of UniProt Q6NS95
Elsewhere: RCSB PDB 5WHJ · PDBe 5WHJ · UniProt S6BAN1 · UniProt Q6NS95

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