MolNFT v1 · #138319 · protein

Tepsin tenth domain 1-136.

5WFB · Ap-4 complex accessory subunit tepsin: “Tepsin tenth domain 1-136.”. X-ray diffraction, 1 pocket (best druggability 0.77). MolNFT v1 #138319 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 5WFB
Type: protein
Length: 263 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Ap-4 complex accessory subunit tepsin
UniProt: Q96N21
Pockets: 1 · best druggability 0.77

Structure

x-ray diffraction · 2 distinct chains · 75% helix, 1% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Ap-4 complex accessory subunit tepsin	protein	132	74% helix, 2% strand	Q96N21
B	Ap-4 complex accessory subunit tepsin	protein	131	76% helix, 0% strand	Q96N21

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	497	0.77	0.84	67	empty

Interfaces

1 interface between chains.

A–B · 784 Å² buried · 6 hydrogen bonds · protein-protein

Compared structures

5WFB · Tepsin tENTH domain 1-136. · the same entry in another collection · chain A against A, TM-score 1.00
Q96N21 · AlphaFold monomer V2.0 prediction for ap-4 complex accessory subunit tepsin (Q96N21) · a predicted model of the same protein · chain B against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q96N21
Elsewhere: RCSB PDB 5WFB · PDBe 5WFB · UniProt Q96N21

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