MolNFT v1 · #138226 · protein + DNA
Human pit-1 and 4XCATT DNA complex
5WC9 · Pituitary-specific positive transcription factor 1: “Human pit-1 and 4XCATT DNA complex”. X-ray diffraction, 12 pockets (best druggability 0.73). MolNFT v1 #138226 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 5WC9
- Type
- protein + DNA
- Length
- 614 residues
- Chains
- 8
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Pituitary-specific positive transcription factor 1; DNA (5'…
- UniProt
- P28069
- Pockets
- 12 · best druggability 0.73
Structure
x-ray diffraction · 7 distinct chains · 69% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| B | Pituitary-specific positive transcription factor 1 | protein | 133 | 69% helix, 0% strand | P28069 |
| A | Pituitary-specific positive transcription factor 1 | protein | 136 | 68% helix, 0% strand | P28069 |
| C, G | DNA (5'- D(*CP*CP*AP*TP*TP*CP*AP*TP*TP*CP*AP*TP*TP*CP*AP*TP*TP*CP*GP*GP*A)- 3') | dna | 20 | — | — |
| D | DNA (5'- D(*CP*CP*GP*AP*AP*TP*GP*AP*AP*TP*GP*AP*AP*TP*GP*AP*AP*TP*GP*GP*T)- 3') | dna | 21 | — | — |
| E | Pituitary-specific positive transcription factor 1 | protein | 132 | 70% helix, 0% strand | P28069 |
| F | Pituitary-specific positive transcription factor 1 | protein | 132 | 69% helix, 0% strand | P28069 |
| H | DNA (5'- D(*CP*CP*GP*AP*AP*TP*GP*AP*AP*TP*GP*AP*AP*TP*GP*AP*AP*TP*GP*GP*T)- 3') | dna | 20 | — | — |
Pockets
12 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 189 | 0.73 | 0.90 | 24 | empty |
| 2 | 976 | 0.72 | 0.76 | 83 | empty |
| 3 | 203 | 0.71 | 0.88 | 25 | empty |
| 4 | 905 | 0.71 | 0.76 | 79 | empty |
| 5 | 78 | 0.68 | 0.94 | 18 | empty |
Interfaces
13 interfaces between chains.
- C–D · 890 Ų buried · 70 hydrogen bonds · nucleic-nucleic
- G–H · 882 Ų buried · 67 hydrogen bonds · nucleic-nucleic
- A–C · 822 Ų buried · 15 hydrogen bonds · protein-nucleic
- E–G · 804 Ų buried · 17 hydrogen bonds · protein-nucleic
- F–G · 767 Ų buried · 15 hydrogen bonds · protein-nucleic
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P28069
- Elsewhere: RCSB PDB 5WC9 · PDBe 5WC9 · UniProt P28069
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