MolNFT v1 · #138218 · protein

Katanin aaa ATPase domain

5WC1 · Meiotic spindle formation protein mei-1: “Katanin aaa ATPase domain”. X-ray diffraction, 1 ligand (SO4), 4 pockets (best druggability 0.66). MolNFT v1 #138218 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 5WC1
Type: protein
Length: 262 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Meiotic spindle formation protein mei-1
EC: 3.6.4.3
UniProt: P34808
Ligands: SO4
Pockets: 4 · best druggability 0.66

Structure

x-ray diffraction · 1 distinct chain · 42% helix, 11% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Meiotic spindle formation protein mei-1 (EC 3.6.4.3)	protein	262	42% helix, 11% strand	P34808

Ligands and binding sites

SO4 · Sulfate ion · ion · 2 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	413	0.66	0.79	42	empty
2	84	0.49	0.83	21	empty
3	62	0.41	0.80	16	empty
4	83	0.37	0.76	23	empty

Compared structures

5WC1 · katanin AAA ATPase domain · the same entry in another collection · chain A against A, TM-score 1.00
P34808 · AlphaFold monomer V2.0 prediction for meiotic spindle formation protein mei-1 (P34808) · a predicted model of the same protein · chain A against A, TM-score 0.94

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P34808
Elsewhere: RCSB PDB 5WC1 · PDBe 5WC1 · UniProt P34808

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