MolNFT v1 · #137994 · protein
Structure of human sts-1 histidine phosphatase domain
5W5G · Ubiquitin-associated and SH3 domain-containing protein B: “Structure of human sts-1 histidine phosphatase domain”. X-ray diffraction, 7 pockets (best druggability 0.80). MolNFT v1 #137994 on GenesisL1: 3D structure, binding sites…
- PDB
- 5W5G
- Type
- protein
- Length
- 771 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Ubiquitin-associated and SH3 domain-containing protein B
- EC
- 3.1.3.48
- UniProt
- Q8TF42
- Pockets
- 7 · best druggability 0.80
Structure
x-ray diffraction · 3 distinct chains · 36% helix, 13% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Ubiquitin-associated and SH3 domain-containing protein B (EC 3.1.3.48) | protein | 262 | 37% helix, 12% strand | Q8TF42 |
| B | Ubiquitin-associated and SH3 domain-containing protein B (EC 3.1.3.48) | protein | 255 | 37% helix, 13% strand | Q8TF42 |
| C | Ubiquitin-associated and SH3 domain-containing protein B (EC 3.1.3.48) | protein | 254 | 35% helix, 13% strand | Q8TF42 |
Pockets
7 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1105 | 0.80 | 0.81 | 104 | empty |
| 2 | 337 | 0.59 | 0.77 | 30 | empty |
| 3 | 268 | 0.58 | 0.78 | 36 | empty |
| 4 | 153 | 0.44 | 0.75 | 26 | empty |
| 5 | 117 | 0.43 | 0.77 | 28 | empty |
Interfaces
3 interfaces between chains.
- A–B · 1612 Ų buried · 23 hydrogen bonds · protein-protein
- B–C · 531 Ų buried · 5 hydrogen bonds · protein-protein
- A–C · 349 Ų buried · 1 hydrogen bond · protein-protein
Compared structures
- 5W5G · Structure of Human Sts-1 histidine phosphatase domain · the same entry in another collection · chain A against A, TM-score 1.00
- Q8TF42 · AlphaFold monomer V2.0 prediction for ubiquitin-associated and SH3 domain-containing… · a predicted model of the same protein · chain C against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8TF42
- Elsewhere: RCSB PDB 5W5G · PDBe 5W5G · UniProt Q8TF42
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