MolNFT v1 · #137983 · protein
Crystal structure of the first bromodomain of human BRD4 in complex with the inhibitor JWG048
5W55: “Crystal structure of the first bromodomain of human BRD4 in complex with the inhibitor JWG048”. X-ray diffraction, 1 ligand (X30). MolNFT v1 #137983 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 5W55
- Type
- protein
- Length
- 123 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- UniProt
- O60885
- Ligands
- X30
Structure
x-ray diffraction · 1 distinct chain.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | — | protein | 123 | — | O60885 |
Ligands and binding sites
- X30 · 11-ethyl-2-({2-methoxy-4-[4-(4-methylpiperazin-1-yl) piperidine-1-carbonyl]phenyl}amino)-5-methyl-5,11-dihydro-6H-pyrimido[4,5-b][1,4]benzodiazepin-6-one · ligand · chains A
- EDO · 1,2-ethanediol · additive · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 5W55 · Crystal Structure of the first bromodomain of human BRD4 in complex with the inhibitor… · the same entry in another collection · chain A against A, TM-score 1.00
- O60885 · AlphaFold monomer V2.0 prediction for bromodomain-containing protein 4 (O60885) · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O60885
- Elsewhere: RCSB PDB 5W55 · PDBe 5W55 · UniProt O60885
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