MolNFT v1 · #137965 · protein
Crystal structure of streptococcus dysgalactiae shp pheromone receptor RGG2(C45S)
5W4N · Transcriptional regulator: “Crystal structure of streptococcus dysgalactiae shp pheromone receptor RGG2(C45S)”. X-ray diffraction, 8 pockets (best druggability 0.74). MolNFT v1 #137965 on GenesisL1: 3D structure, binding sites and…
- PDB
- 5W4N
- Type
- protein
- Length
- 546 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Transcriptional regulator
- UniProt
- A0A0J9X288
- Pockets
- 8 · best druggability 0.74
Structure
x-ray diffraction · 2 distinct chains · 73% helix, 1% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Transcriptional regulator | protein | 273 | 73% helix, 2% strand | A0A0J9X288 |
| B | Transcriptional regulator | protein | 273 | 73% helix, 1% strand | A0A0J9X288 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
8 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1174 | 0.74 | 0.77 | 97 | GOL, DMS |
| 2 | 100 | 0.65 | 0.90 | 19 | empty |
| 3 | 144 | 0.59 | 0.84 | 30 | empty |
| 4 | 74 | 0.57 | 0.88 | 19 | DMS |
| 5 | 121 | 0.42 | 0.76 | 16 | DMS |
Interfaces
1 interface between chains.
- A–B · 2907 Ų buried · 33 hydrogen bonds · protein-protein
Compared structures
- 5W4N · Crystal structure of Streptococcus dysgalactiae SHP pheromone receptor Rgg2(C45S) · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A0A0J9X288
- Elsewhere: RCSB PDB 5W4N · PDBe 5W4N · UniProt A0A0J9X288
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