MolNFT v1 · #13795 · protein

Retro-diels-alderase catalytic antibody 9D9

1LO4 · If kappa light chain: “Retro-diels-alderase catalytic antibody 9D9”. X-ray diffraction, 4 pockets (best druggability 0.67). MolNFT v1 #13795 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 1LO4
Type: protein
Length: 437 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: If kappa light chain; Ig gamma 2A heavy chain
UniProt: Q99M37
Pockets: 4 · best druggability 0.67

Structure

x-ray diffraction · 2 distinct chains · 5% helix, 52% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
L	If kappa light chain	protein	217	6% helix, 52% strand	Q99M37
H	Ig gamma 2A heavy chain	protein	220	4% helix, 53% strand	—

Pockets

4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	132	0.67	0.89	24	empty
2	540	0.63	0.75	51	empty
3	121	0.41	0.75	24	empty
4	99	0.37	0.75	17	empty

Interfaces

1 interface between chains.

L–H · 1993 Å² buried · 23 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 4 disulfide (disulfide).

Compared structures

1LO4 · Retro-Diels-Alderase Catalytic antibody 9D9 · the same entry in another collection · chain L against L, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q99M37
Elsewhere: RCSB PDB 1LO4 · PDBe 1LO4 · UniProt Q99M37

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.