MolNFT v1 · #137893 · protein
Crystal structure of dimeric form of mouse glutaminase C
5W2J · Glutaminase kidney isoform, mitochondrial: “Crystal structure of dimeric form of mouse glutaminase C”. X-ray diffraction, 1 ligand (CL), 8 pockets (best druggability 0.69). MolNFT v1 #137893 on GenesisL1: 3D structure, binding sites…
- PDB
- 5W2J
- Type
- protein
- Length
- 833 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Glutaminase kidney isoform, mitochondrial; Unidentified peptide
- EC
- 3.5.1.2
- UniProt
- D3Z7P3
- Ligands
- CL
- Pockets
- 8 · best druggability 0.69
Structure
x-ray diffraction · 3 distinct chains · 49% helix, 11% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Glutaminase kidney isoform, mitochondrial (EC 3.5.1.2) | protein | 408 | 49% helix, 11% strand | D3Z7P3 |
| B | Glutaminase kidney isoform, mitochondrial (EC 3.5.1.2) | protein | 411 | 48% helix, 11% strand | D3Z7P3 |
| F | Unidentified peptide | protein | 14 | 86% helix, 0% strand | — |
Ligands and binding sites
- CL · Chloride ion · ion · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
8 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 412 | 0.69 | 0.81 | 39 | empty |
| 2 | 320 | 0.65 | 0.81 | 38 | CL |
| 3 | 260 | 0.64 | 0.82 | 39 | empty |
| 4 | 258 | 0.62 | 0.80 | 38 | empty |
| 5 | 315 | 0.60 | 0.78 | 32 | CL |
Interfaces
2 interfaces between chains.
- A–B · 1825 Ų buried · 24 hydrogen bonds · protein-protein
- B–F · 426 Ų buried · 4 hydrogen bonds · protein-protein
Compared structures
- 5W2J · Crystal structure of dimeric form of mouse Glutaminase C · the same entry in another collection · chain A against A, TM-score 1.00
- D3Z7P3 · AlphaFold monomer V2.0 prediction for glutaminase kidney isoform, mitochondrial (D3Z7P3) · a predicted model of the same protein · chain B against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt D3Z7P3
- Elsewhere: RCSB PDB 5W2J · PDBe 5W2J · UniProt D3Z7P3
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