MolNFT v1 · #137851 · protein
The first X-ray crystal structure of an insect muscle myosin. drosophila melanogaster, skeletal muscle myosin II, an embryonic isoform, subfragment-1
5W1A · Myosin heavy chain, muscle: “The first X-ray crystal structure of an insect muscle myosin. drosophila melanogaster, skeletal muscle myosin…”. X-ray diffraction, 20 pockets (best druggability 0.84). MolNFT v1 #137851 on GenesisL1: 3D…
- PDB
- 5W1A
- Type
- protein
- Length
- 1,876 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Myosin heavy chain, muscle; Myosin light chain alkali
- UniProt
- P05661, P06742
- Pockets
- 20 · best druggability 0.84
Structure
x-ray diffraction · 4 distinct chains · 50% helix, 14% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Myosin heavy chain, muscle | protein | 786 | 48% helix, 16% strand | P05661 |
| B | Myosin light chain alkali | protein | 154 | 56% helix, 8% strand | P06742 |
| C | Myosin heavy chain, muscle | protein | 785 | 49% helix, 15% strand | P05661 |
| D | Myosin light chain alkali | protein | 151 | 56% helix, 8% strand | P06742 |
Ligands and binding sites
- GOL · Glycerol · additive · 4 copies · chains A, C
- EDO · 1,2-ethanediol · additive · 4 copies · chains A, C
- FLC · Citrate anion · additive · 2 copies · chains A, C
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
20 pockets found on a 1 Å grid, 9 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 982 | 0.84 | 0.85 | 113 | FLC, GOL |
| 2 | 1016 | 0.78 | 0.80 | 98 | empty |
| 3 | 925 | 0.77 | 0.80 | 84 | empty |
| 4 | 220 | 0.76 | 0.91 | 41 | empty |
| 5 | 963 | 0.76 | 0.79 | 91 | FLC |
Interfaces
3 interfaces between chains.
- A–B · 2081 Ų buried · 22 hydrogen bonds · protein-protein
- C–D · 2027 Ų buried · 19 hydrogen bonds · protein-protein
- A–C · 540 Ų buried · 2 hydrogen bonds · protein-protein
Compared structures
- 5W1A · The first X-ray crystal structure of an insect muscle myosin. Drosophila melanogaster… · the same entry in another collection · chain D against D, TM-score 1.00
- P06742 · AlphaFold monomer V2.0 prediction for myosin light chain alkali (P06742) · a predicted model of the same protein · chain B against A, TM-score 0.95
- P05661 · AlphaFold monomer V2.0 prediction for myosin heavy chain, muscle (P05661) · a predicted model of the same protein · chain A against A, TM-score 0.80
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P05661
- Every structure of UniProt P06742
- Elsewhere: RCSB PDB 5W1A · PDBe 5W1A · UniProt P05661 · UniProt P06742
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