MolNFT v1 · #137836 · protein

Crystal structure of full-length kluyveromyces lactis KAP123 with histone H4 1-34

5W0V: “Crystal structure of full-length kluyveromyces lactis KAP123 with histone H4 1-34”. X-ray diffraction, 20 pockets (best druggability 0.71). MolNFT v1 #137836 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 5W0V
Type: protein
Length: 2,033 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: KAP123; Histone H4 1-34
UniProt: Q6CMF0
Pockets: 20 · best druggability 0.71

Structure

x-ray diffraction · 4 distinct chains · 78% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	KAP123	protein	1017	78% helix, 0% strand	Q6CMF0
B	KAP123	protein	1003	79% helix, 0% strand	Q6CMF0
C	Histone H4 1-34	protein	7	0% helix, 0% strand	—
D	Histone H4 1-34	protein	6	0% helix, 0% strand	—

Pockets

20 pockets found on a 1 Å grid, 9 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	533	0.71	0.80	65	empty
2	241	0.61	0.81	35	empty
3	339	0.61	0.78	36	empty
4	252	0.55	0.77	39	empty
5	248	0.55	0.77	28	empty

Interfaces

3 interfaces between chains.

A–B · 585 Å² buried · 1 hydrogen bond · protein-protein
A–C · 563 Å² buried · 11 hydrogen bonds · protein-protein
B–D · 546 Å² buried · 9 hydrogen bonds · protein-protein

Compared structures

5W0V · Crystal structure of full-length Kluyveromyces lactis Kap123 with histone H4 1-34 · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q6CMF0
Elsewhere: RCSB PDB 5W0V · PDBe 5W0V · UniProt Q6CMF0

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