MolNFT v1 · #137696 · protein

Crystal structure of human scribble PDZ1:BETA-pix complex

5VWI · Protein scribble homolog: “Crystal structure of human scribble PDZ1:BETA-pix complex”. X-ray diffraction, 1 pocket (best druggability 0.44). MolNFT v1 #137696 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 5VWI
Type: protein
Length: 195 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Protein scribble homolog; Beta-pix
UniProt: Q14160
Pockets: 1 · best druggability 0.44

Structure

x-ray diffraction · 3 distinct chains · 13% helix, 35% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Protein scribble homolog	protein	92	13% helix, 35% strand	Q14160
B	Protein scribble homolog	protein	87	15% helix, 36% strand	Q14160
C, D	Beta-pix	protein	8	0% helix, 25% strand	—

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	134	0.44	0.76	25	empty

Interfaces

3 interfaces between chains.

B–D · 502 Å² buried · 12 hydrogen bonds · protein-protein
A–C · 502 Å² buried · 13 hydrogen bonds · protein-protein
A–B · 481 Å² buried · 19 hydrogen bonds · protein-protein

Compared structures

5VWI · Crystal structure of human Scribble PDZ1:Beta-PIX complex · the same entry in another collection · chain A against A, TM-score 1.00
Q14160 · AlphaFold monomer V2.0 prediction for protein scribble homolog (Q14160) · a predicted model of the same protein · chain B against A, TM-score 0.91

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q14160
Elsewhere: RCSB PDB 5VWI · PDBe 5VWI · UniProt Q14160

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