MolNFT v1 · #13765 · protein
Structure of the catalytic domain of homing endonuclease I-tevi
1LN0 · Intron-associated endonuclease 1: “Structure of the catalytic domain of homing endonuclease I-tevi”. X-ray diffraction, 1 ligand (SO4), 1 pocket (best druggability 0.51). MolNFT v1 #13765 on GenesisL1: 3D structure, binding sites…
- PDB
- 1LN0
- Type
- protein
- Length
- 186 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Intron-associated endonuclease 1
- EC
- 3.1.-.-
- UniProt
- P13299
- Ligands
- SO4
- Pockets
- 1 · best druggability 0.51
Structure
x-ray diffraction · 2 distinct chains · 41% helix, 23% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Intron-associated endonuclease 1 (EC 3.1.-.-) | protein | 92 | 41% helix, 23% strand | P13299 |
| B | Intron-associated endonuclease 1 (EC 3.1.-.-) | protein | 94 | 41% helix, 22% strand | P13299 |
Ligands and binding sites
- SO4 · Sulfate ion · ion · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 324 | 0.51 | 0.73 | 52 | empty |
Interfaces
1 interface between chains.
- A–B · 173 Ų buried · 1 hydrogen bond · protein-protein
Modifications
Observed in the structure: 1 disulfide (disulfide).
Compared structures
- 1LN0 · Structure of the Catalytic Domain of Homing Endonuclease I-TevI · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P13299
- Elsewhere: RCSB PDB 1LN0 · PDBe 1LN0 · UniProt P13299
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