MolNFT v1 · #137616 · protein

Tna polymerase, apo

5VU5 · DNA polymerase: “Tna polymerase, apo”. X-ray diffraction, 15 pockets (best druggability 0.62). MolNFT v1 #137616 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 5VU5
Type: protein
Length: 707 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: DNA polymerase
EC: 2.7.7.7
UniProt: D0VWU9
Pockets: 15 · best druggability 0.62

Structure

x-ray diffraction · 1 distinct chain · 38% helix, 20% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	DNA polymerase (EC 2.7.7.7)	protein	707	38% helix, 20% strand	D0VWU9

Pockets

15 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	295	0.62	0.79	34	empty
2	283	0.61	0.79	26	empty
3	370	0.59	0.76	38	empty
4	144	0.58	0.83	20	empty
5	130	0.54	0.81	19	empty

Modifications

Observed in the structure: 2 disulfide (disulfide).

Compared structures

5VU5 · TNA polymerase, apo · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt D0VWU9
Elsewhere: RCSB PDB 5VU5 · PDBe 5VU5 · UniProt D0VWU9

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