MolNFT v1 · #137588 · protein

Myosin light chain 1 and myoa complex

5VT9 · Myosin light chain TGMLC1: “Myosin light chain 1 and myoa complex”. X-ray diffraction, 1 pocket (best druggability 0.73). MolNFT v1 #137588 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 5VT9
Type: protein
Length: 331 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Myosin light chain TGMLC1; Myosin-a
UniProt: Q95UJ7, O00934
Pockets: 1 · best druggability 0.73

Structure

x-ray diffraction · 4 distinct chains · 60% helix, 6% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Myosin light chain TGMLC1	protein	134	60% helix, 6% strand	Q95UJ7
C	Myosin-a	protein	30	57% helix, 0% strand	O00934
B	Myosin light chain TGMLC1	protein	139	61% helix, 9% strand	Q95UJ7
D	Myosin-a	protein	28	57% helix, 0% strand	O00934

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	388	0.73	0.84	56	empty

Interfaces

6 interfaces between chains.

A–C · 1542 Å² buried · 23 hydrogen bonds · protein-protein
B–D · 1533 Å² buried · 24 hydrogen bonds · protein-protein
A–B · 363 Å² buried · 8 hydrogen bonds · protein-protein
A–D · 313 Å² buried · 4 hydrogen bonds · protein-protein
C–B · 256 Å² buried · 4 hydrogen bonds · protein-protein

Compared structures

5VT9 · Myosin Light chain 1 and MyoA complex · the same entry in another collection · chain A against A, TM-score 1.00
O00934 · AlphaFold monomer V2.0 prediction for myosin-a (O00934) · a predicted model of the same protein · chain D against A, TM-score 0.62

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q95UJ7
Every structure of UniProt O00934
Elsewhere: RCSB PDB 5VT9 · PDBe 5VT9 · UniProt Q95UJ7 · UniProt O00934

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