MolNFT v1 · #137579 · protein
Structure of the ubl domain of sacsin mutant L78M
5VSZ: “Structure of the ubl domain of sacsin mutant L78M”. X-ray diffraction, 1 pocket (best druggability 0.72). MolNFT v1 #137579 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 5VSZ
- Type
- protein
- Length
- 138 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Sacsin
- UniProt
- Q9NZJ4
- Pockets
- 1 · best druggability 0.72
Structure
x-ray diffraction · 2 distinct chains · 27% helix, 10% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Sacsin | protein | 70 | 27% helix, 10% strand | Q9NZJ4 |
| B | Sacsin | protein | 68 | 26% helix, 10% strand | Q9NZJ4 |
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 696 | 0.72 | 0.78 | 59 | empty |
Interfaces
1 interface between chains.
- A–B · 232 Ų buried · 1 hydrogen bond · protein-protein
Modifications
Observed in the structure: 2 disulfide, 2 modified (disulfide, engineered).
Compared structures
- 5VSZ · Structure of the Ubl domain of Sacsin mutant L78M · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9NZJ4
- Elsewhere: RCSB PDB 5VSZ · PDBe 5VSZ · UniProt Q9NZJ4
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