MolNFT v1 · #13753 · protein

Leishmanolysin

1LML: “Leishmanolysin”. X-ray diffraction, 1 ligand (ZN), 5 pockets (best druggability 0.57). MolNFT v1 #13753 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 1LML
Type: protein
Length: 465 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Leishmanolysin
EC: 3.4.24.36
UniProt: P08148
Ligands: ZN
Pockets: 5 · best druggability 0.57

Structure

x-ray diffraction · 1 distinct chain · 24% helix, 25% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Leishmanolysin (EC 3.4.24.36)	protein	465	24% helix, 25% strand	P08148

Ligands and binding sites

ZN · Zinc ion · metal · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

5 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	280	0.57	0.77	47	empty
2	138	0.45	0.77	22	empty
3	177	0.45	0.75	23	empty
4	130	0.41	0.75	30	empty
5	56	0.32	0.76	12	empty

Modifications

Observed in the structure: 9 disulfide (disulfide).

Compared structures

1LML · Leishmanolysin · the same entry in another collection · chain A against A, TM-score 1.00
P08148 · AlphaFold monomer V2.0 prediction for leishmanolysin (P08148) · a predicted model of the same protein · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P08148
Elsewhere: RCSB PDB 1LML · PDBe 1LML · UniProt P08148

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