MolNFT v1 · #13746 · protein + DNA
Refined 1.8 ångström crystal structure of the lambda repressor-operator complex
1LMB · DNA (5'- D(*AP*AP*TP*AP*CP*CP*AP*CP*TP*GP*GP*CP*GP*GP*TP*GP*…: “Refined 1.8 ångström crystal structure of the lambda repressor-operator complex”. X-ray diffraction, 3 pockets (best druggability 0.56). MolNFT v1 #13746 on GenesisL1…
- PDB
- 1LMB
- Type
- protein + DNA
- Length
- 219 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- DNA (5'- D(*AP*AP*TP*AP*CP*CP*AP*CP*TP*GP*GP*CP*GP*GP*TP*GP*A P*TP*AP*T)-3'); DNA (5'…
- UniProt
- P03034
- Pockets
- 3 · best druggability 0.56
Structure
x-ray diffraction · 4 distinct chains · 69% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| 1 | DNA (5'- D(*AP*AP*TP*AP*CP*CP*AP*CP*TP*GP*GP*CP*GP*GP*TP*GP*A P*TP*AP*T)-3') | dna | 20 | — | — |
| 2 | DNA (5'- D(*TP*AP*TP*AP*TP*CP*AP*CP*CP*GP*CP*CP*AP*GP*TP*GP*G P*TP*AP*T)-3') | dna | 20 | — | — |
| 3 | Protein (lambda repressor) | protein | 87 | 71% helix, 0% strand | P03034 |
| 4 | Protein (lambda repressor) | protein | 92 | 67% helix, 0% strand | P03034 |
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 371 | 0.56 | 0.75 | 44 | empty |
| 2 | 88 | 0.40 | 0.78 | 18 | empty |
| 3 | 57 | 0.30 | 0.75 | 14 | empty |
Interfaces
6 interfaces between chains.
- 1–2 · 871 Ų buried · 69 hydrogen bonds · nucleic-nucleic
- 3–4 · 765 Ų buried · 8 hydrogen bonds · protein-protein
- 1–4 · 548 Ų buried · 12 hydrogen bonds · protein-nucleic
- 2–4 · 492 Ų buried · 9 hydrogen bonds · protein-nucleic
- 2–3 · 315 Ų buried · 7 hydrogen bonds · protein-nucleic
Compared structures
- 1LMB · Refined 1.8 ångström crystal structure of the lambda repressor-operator complex · the same entry in another collection · chain 1 against 1, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P03034
- Elsewhere: RCSB PDB 1LMB · PDBe 1LMB · UniProt P03034
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