MolNFT v1 · #13743 · protein

Structures of two intermediate filament-binding fragments of desmoplakin reveal a unique repeat motif structure

1LM7 · Subdomain of desmoplakin carboxy-terminal domain (dpct): “Structures of two intermediate filament-binding fragments of desmoplakin reveal a unique repeat motif…”. X-ray diffraction, 5 pockets (best druggability 0.79). MolNFT v1…

PDB: 1LM7
Type: protein
Length: 476 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Subdomain of desmoplakin carboxy-terminal domain (dpct)
UniProt: P15924
Pockets: 5 · best druggability 0.79

Structure

x-ray diffraction · 1 distinct chain · 36% helix, 17% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Subdomain of desmoplakin carboxy-terminal domain (dpct)	protein	238	36% helix, 17% strand	P15924

Pockets

5 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	712	0.79	0.83	71	empty
2	81	0.56	0.87	20	empty
3	90	0.52	0.84	19	empty
4	83	0.47	0.82	11	empty
5	51	0.31	0.77	16	empty

Interfaces

1 interface between chains.

A–B · 986 Å² buried · 19 hydrogen bonds · protein-protein

Compared structures

1LM7 · Structures of two intermediate filament-binding fragments of desmoplakin reveal a unique… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P15924
Elsewhere: RCSB PDB 1LM7 · PDBe 1LM7 · UniProt P15924

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