MolNFT v1 · #137358 · protein
Pseudo-atomic model of the mura-A2 complex
5VM7 · Maturation protein A2: “Pseudo-atomic model of the mura-A2 complex”. Electron microscopy, 11 pockets (best druggability 0.84). MolNFT v1 #137358 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 5VM7
- Type
- protein
- Length
- 838 residues
- Chains
- 2
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Maturation protein A2; Udp-N-acetylglucosamine 1-carboxyvinyltransferase
- EC
- 2.5.1.7
- UniProt
- Q8LTE2, A7ZS86
- Pockets
- 11 · best druggability 0.84
Structure
electron microscopy · 2 distinct chains · 27% helix, 18% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Maturation protein A2 | protein | 419 | 29% helix, 19% strand | Q8LTE2 |
| B | Udp-N-acetylglucosamine 1-carboxyvinyltransferase (EC 2.5.1.7) | protein | 419 | 25% helix, 17% strand | A7ZS86 |
Pockets
11 pockets found on a 1 Å grid, 7 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 378 | 0.84 | 0.92 | 59 | empty |
| 2 | 418 | 0.81 | 0.89 | 63 | empty |
| 3 | 447 | 0.76 | 0.85 | 54 | empty |
| 4 | 90 | 0.72 | 0.95 | 21 | empty |
| 5 | 82 | 0.71 | 0.94 | 23 | empty |
Interfaces
1 interface between chains.
- A–B · 1532 Ų buried · 9 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8LTE2
- Every structure of UniProt A7ZS86
- Elsewhere: RCSB PDB 5VM7 · PDBe 5VM7 · UniProt Q8LTE2 · UniProt A7ZS86
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