MolNFT v1 · #137321 · protein
Crystal structure of MDM12 and combinatorial reconstitution of MDM12/MMM1 ermes complexes for structural studies
5VKZ · Mitochondrial distribution and morphology protein 12: “Crystal structure of MDM12 and combinatorial reconstitution of MDM12/MMM1 ermes complexes for structural…”. X-ray diffraction, 3 pockets (best druggability 0.78). MolNFT v1…
- PDB
- 5VKZ
- Type
- protein
- Length
- 428 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Mitochondrial distribution and morphology protein 12
- UniProt
- B5VRP4
- Pockets
- 3 · best druggability 0.78
Structure
x-ray diffraction · 2 distinct chains · 29% helix, 38% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Mitochondrial distribution and morphology protein 12 | protein | 216 | 29% helix, 38% strand | B5VRP4 |
| B | Mitochondrial distribution and morphology protein 12 | protein | 212 | 29% helix, 39% strand | B5VRP4 |
Pockets
3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 494 | 0.78 | 0.85 | 62 | empty |
| 2 | 240 | 0.69 | 0.85 | 33 | empty |
| 3 | 78 | 0.50 | 0.84 | 21 | empty |
Interfaces
1 interface between chains.
- A–B · 901 Ų buried · 12 hydrogen bonds · protein-protein
Compared structures
- 5VKZ · Crystal structure of Mdm12 and combinatorial reconstitution of Mdm12/Mmm1 ERMES complexes… · the same entry in another collection · chain A against A, TM-score 1.00
- B5VRP4 · AlphaFold monomer V2.0 prediction for mitochondrial distribution and morphology protein… · a predicted model of the same protein · chain A against A, TM-score 0.93
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt B5VRP4
- Elsewhere: RCSB PDB 5VKZ · PDBe 5VKZ · UniProt B5VRP4
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