MolNFT v1 · #137320 · protein
Yeast TDA2 (YER071C) - a dynein light chain family member that works independently of the dynein motor complex and microtubules.
5VKY · Topoisomerase I damage affected protein 2: “Yeast TDA2 (YER071C) - a dynein light chain family member that works independently of the dynein motor…”. X-ray diffraction, 2 pockets (best druggability 0.42). MolNFT v1 #137320 on…
- PDB
- 5VKY
- Type
- protein
- Length
- 227 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Topoisomerase I damage affected protein 2
- UniProt
- C7GRQ3
- Pockets
- 2 · best druggability 0.42
Structure
x-ray diffraction · 2 distinct chains · 30% helix, 37% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Topoisomerase I damage affected protein 2 | protein | 122 | 31% helix, 34% strand | C7GRQ3 |
| B | Topoisomerase I damage affected protein 2 | protein | 105 | 30% helix, 40% strand | C7GRQ3 |
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 102 | 0.42 | 0.77 | 18 | empty |
| 2 | 57 | 0.29 | 0.75 | 12 | empty |
Interfaces
1 interface between chains.
- A–B · 1539 Ų buried · 40 hydrogen bonds · protein-protein
Compared structures
- 5VKY · Yeast Tda2 (YER071C) - a dynein light chain family member that works independently of the… · the same entry in another collection · chain A against A, TM-score 1.00
- C7GRQ3 · AlphaFold monomer V2.0 prediction for topoisomerase I damage affected protein 2 (C7GRQ3) · a predicted model of the same protein · chain B against A, TM-score 0.87
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt C7GRQ3
- Elsewhere: RCSB PDB 5VKY · PDBe 5VKY · UniProt C7GRQ3
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