MolNFT v1 · #137144 · protein
Ritr mutant - C128D
5VFA · Response regulator: “Ritr mutant - C128D”. X-ray diffraction, 7 pockets (best druggability 0.66). MolNFT v1 #137144 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 5VFA
- Type
- protein
- Length
- 442 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Response regulator
- UniProt
- Q8DR53
- Pockets
- 7 · best druggability 0.66
Structure
x-ray diffraction · 2 distinct chains · 43% helix, 21% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Response regulator | protein | 220 | 44% helix, 20% strand | Q8DR53 |
| B | Response regulator | protein | 222 | 43% helix, 21% strand | Q8DR53 |
Pockets
7 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 585 | 0.66 | 0.76 | 63 | empty |
| 2 | 163 | 0.53 | 0.80 | 23 | empty |
| 3 | 156 | 0.52 | 0.79 | 23 | empty |
| 4 | 112 | 0.45 | 0.78 | 20 | empty |
| 5 | 94 | 0.42 | 0.78 | 19 | empty |
Interfaces
1 interface between chains.
- A–B · 247 Ų buried · 2 hydrogen bonds · protein-protein
Compared structures
- 5VFA · RitR Mutant - C128D · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8DR53
- Elsewhere: RCSB PDB 5VFA · PDBe 5VFA · UniProt Q8DR53
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